Oien Derek B, Moskovitz Jackob
Department of Pharmacology and Toxicology, School of Pharmacy, University of Kansas, Lawrence, KS 66045, USA.
Molecules. 2009 Jul 1;14(7):2337-44. doi: 10.3390/molecules14072337.
Selenium is a chemical element participating in the synthesis of selenocysteine residues that play a pivotal role in the enzymatic activity efficiency of selenoproteines. The methionine sulfoxide reductase (Msr) system that reduces methionine sulfoxide (MetO) to methionine comprises the selenoprotein MsrB (MsrB1) and the non-selenoprotein MsrA, which reduce the R- and the S- forms of MetO, respectively. The effects of a selenium deficient (SD) diet, which was administrated to wild type (WT) and MsrA knockout mice (MsrA(-)/(-)), on the expression and function of Msr-related proteins are examined and discussed. Additionally, new data about the levels of selenium in brain, liver, and kidneys of WT and MsrA(-)/(-) mice are presented and discussed.
硒是一种参与硒代半胱氨酸残基合成的化学元素，而硒代半胱氨酸残基在硒蛋白的酶活性效率中起着关键作用。将甲硫氨酸亚砜（MetO）还原为甲硫氨酸的甲硫氨酸亚砜还原酶（Msr）系统由硒蛋白MsrB（MsrB1）和非硒蛋白MsrA组成，它们分别还原MetO的R型和S型。研究并讨论了给予野生型（WT）和MsrA基因敲除小鼠（MsrA(-)/(-)）缺硒（SD）饮食对Msr相关蛋白表达和功能的影响。此外，还展示并讨论了关于WT和MsrA(-)/(-)小鼠脑、肝和肾中硒水平的新数据。
