放射性标记氨基酸诊断脑胶质瘤。
Diagnostics of cerebral gliomas with radiolabeled amino acids.
机构信息
Institut für Neurowissenschaften und Biophysik, Forschungszentrum Jülich, Leo-Brandt-Strasse, Jülich, Germany.
出版信息
Dtsch Arztebl Int. 2008 Jan;105(4):55-61. doi: 10.3238/arztebl.2008.0055. Epub 2008 Jan 25.
INTRODUCTION
Magnetic resonance tomography (MRT) is the investigation of choice for diagnosing cerebral glioma, but its capacity to differentiate tumor tissue from non-specific tissue changes is limited. Positron emission tomography (PET) and single photon emission computerized tomography (SPECT) using radiolabeled amino acids add information which helps increase diagnostic accuracy.
METHODS
Review based on the authors' own research results and a selective literature review.
RESULTS
The use of radiolabeled amino acids allows better delineation of tumor margins and improves targeting of biopsy and radiotherapy, and planning surgery. In addition, amino acid imaging appears useful in distinguishing tumor recurrence from non-specific post-therapeutic scar tissue, in predicting prognosis in low grade gliomas, and in monitoring metabolic response during treatment.
DISCUSSION
The benefits of amino acid imaging in cerebral gliomas support arguments for its introduction into routine clinical practice in defined clinical situations; however, its influence on treatment quality remains to be demonstrated.
简介
磁共振成像（MRT）是诊断脑胶质瘤的首选方法，但它区分肿瘤组织与非特异性组织变化的能力有限。使用放射性标记氨基酸的正电子发射断层扫描（PET）和单光子发射计算机断层扫描（SPECT）可提供有助于提高诊断准确性的信息。
方法
基于作者自己的研究结果和选择性文献回顾的综述。
结果
放射性标记氨基酸的使用可以更好地区分肿瘤边界，并有助于活检和放疗靶向以及手术计划。此外，氨基酸成像似乎可用于区分肿瘤复发与非特异性治疗后疤痕组织，预测低级别胶质瘤的预后，并在治疗过程中监测代谢反应。
讨论
氨基酸成像在脑胶质瘤中的益处支持了在特定临床情况下将其引入常规临床实践的论点；然而，它对治疗质量的影响仍有待证明。
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