自身免疫领域中的表观遗传学革命。
The revolution of epigenetics in the field of autoimmunity.
机构信息
EA2219 Immunology and Pathology, IFR148 ScinBios, Université de Brest, Brest, France.
出版信息
Clin Rev Allergy Immunol. 2010 Aug;39(1):1-2. doi: 10.1007/s12016-009-8171-9.
PMID:19633961
Abstract
Autoimmunity is believed to develop when genetically predisposed individuals encounter epigenetic modifications in response to environmental factors. Recent advances in the understanding of epigenetic mechanisms, their contribution to the immune function, and to the development of autoimmunity are presented in this special issue of Clinical Reviews in Allergy and Immunology. Potential new therapeutic strategies and biomarkers are also addressed.
摘要
自身免疫被认为是在遗传易感性个体对环境因素产生的表观遗传修饰做出反应时发展起来的。《临床变态反应与免疫学评论》本期特刊介绍了对表观遗传机制的理解进展、它们对免疫功能和自身免疫发生的贡献，以及潜在的新治疗策略和生物标志物。
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