Division of Rheumatology, Department of Internal Medicine, Michigan Medicine, University of Michigan, Ann Arbor, MI 48109, United States.
Division of Geriatric and Palliative Medicine, Department of Internal Medicine, Michigan Medicine, University of Michigan, Ann Arbor, MI 48109, United States.
Clin Immunol. 2018 Nov;196:59-63. doi: 10.1016/j.clim.2018.04.002. Epub 2018 Apr 11.
Aging of the immune system in humans and animals is characterized by a decline in both adaptive and innate immune responses. Paradoxically, aging is also associated with a state of chronic inflammation ("inflammaging") and an increased likelihood of developing autoimmune diseases. Epigenetic changes in non-dividing and dividing cells, including immune cells, due to environmental factors contribute to the inflammation and autoimmunity that characterize both the state and diseases of aging. Here, we review the epigenetic mechanisms involved in the development of immune senescence and autoimmunity in old age.
人类和动物的免疫系统衰老的特征是适应性和先天免疫反应都下降。矛盾的是，衰老也与慢性炎症状态（“炎症衰老”）和自身免疫性疾病的发病风险增加有关。由于环境因素，包括免疫细胞在内的非分裂和分裂细胞中的表观遗传变化导致了炎症和自身免疫，这两种状态和疾病都与衰老有关。在这里，我们综述了参与老年免疫衰老和自身免疫发展的表观遗传机制。
