Schriner Samuel E, Abrahamyan Ani, Avanessian Agnesa, Bussel Irvin, Maler Steven, Gazarian Maral, Holmbeck Marissa A, Jafari Mahtab
Department of Pharmaceutical Sciences, University of California, Irvine, Irvine, CA 92697, USA.
Free Radic Res. 2009 Sep;43(9):836-43. doi: 10.1080/10715760903089724. Epub 2009 Jul 24.
The root extract from Rhodiola rosea has been reported to have numerous health benefits in human and animal studies. Its molecular mechanism is currently unknown; however, it has been suggested to act as an antioxidant. This study found that a formulation of R. rosea extract, SHR-5, from the Swedish Herbal Institute (SHI) could extend both mean (24% in both sexes) and maximum (16% in males and 31% in females) life span in Drosophila melanogaster when compared to controls. It also found that it lowered mitochondrial superoxide levels and afforded elevated protection against the superoxide generator paraquat in both sexes. The extract SHR-5 did not alter the activities of the major antioxidant enzymes, the superoxide dismutases or catalase, nor did it afford protection against H(2)O(2) or soluble iron. These results present a decrease in endogenous superoxide levels as a possible mode of action for the root extract of R. rosea.
在人体和动物研究中，红景天的根提取物已被报道具有多种健康益处。其分子机制目前尚不清楚；然而，有人认为它具有抗氧化作用。本研究发现，来自瑞典草药研究所（SHI）的红景天提取物SHR-5制剂，与对照组相比，可延长黑腹果蝇的平均寿命（两性均延长24%）和最长寿命（雄性延长16%，雌性延长31%）。研究还发现，它降低了线粒体超氧化物水平，并在两性中提供了更高的针对超氧化物产生剂百草枯的保护作用。提取物SHR-5没有改变主要抗氧化酶（超氧化物歧化酶或过氧化氢酶）的活性，也没有提供针对H₂O₂或可溶性铁的保护作用。这些结果表明，内源性超氧化物水平的降低可能是红景天根提取物的一种作用方式。
