The CAS Key Laboratory of Engineering Plastics, Institute of Chemistry, Chinese Academy of Sciences (CAS), Beijing 100190, China.
Macromol Biosci. 2009 Nov 10;9(11):1080-9. doi: 10.1002/mabi.200900104.
An amphiphilic diblock copolymer PG-b-PCL with well-controlled structure and pendant hydroxyl groups along hydrophilic block was synthesized by sequential anionic ring-opening polymerization. The micellization and drug release of PG-b-PCL copolymers using pyrene as a fluorescence probe were investigated for determining the influences of copolymer composition and lipase concentration on drug loading capacity and controlled release behavior. The biodegradation of PG-b-PCL copolymers was studied with microspheres as research samples. It has been concluded that the polar hydroxyl groups along each repeat unit of hydrophilic PG block in PG-b-PCL copolymer have great influences on drug encapsulation, drug release, and enzymatic degradation of micelles and microspheres.
一种具有良好控制结构的两亲性嵌段共聚物 PG-b-PCL，其亲水性链段上带有侧羟基，通过顺序阴离子开环聚合合成。使用芘作为荧光探针研究了 PG-b-PCL 共聚物的胶束化和药物释放，以确定共聚物组成和脂肪酶浓度对载药量和控制释放行为的影响。以微球为研究样品研究了 PG-b-PCL 共聚物的生物降解性。结果表明，PG-b-PCL 共聚物亲水性 PG 嵌段每个重复单元上的极性羟基对药物包封、药物释放以及胶束和微球的酶降解有很大影响。
