伊朗茴香精油对鲍曼不动杆菌分离株的抗菌作用。

Antibacterial effects of Iranian fennel essential oil on isolates of Acinetobacter baumannii.

作者信息

Jazani N H, Zartoshti M, Babazadeh H, Ali-daiee N, Zarrin S, Hosseini S

机构信息

Department of Microbiology, Immunology and Genetics, Faculty of Medicine, Urmia University of Medical Sciences, Urmia, Iran.

出版信息

Pak J Biol Sci. 2009 May 1;12(9):738-41. doi: 10.3923/pjbs.2009.738.741.

DOI:10.3923/pjbs.2009.738.741

PMID:19634482

Abstract

The aim of the present study was the evaluation of the antibacterial activity of Fennel essential oil on isolates of Acinetobacter baumannii. Forty eight isolates were collected from clinical specimens from burn wards of hospitals in Tehran, Iran between April and September, 2006. The susceptibility of isolates was determined using a broth microdilution method. Minimum Inhibitory Concentration (MIC) and Minimum Bactericidal Concentration (MBC) of isolates to Fennel essential oil were determined. The susceptibilities of isolates to different antibiotics were tested using agar disk diffusion method. The rates of resistance were determined to antibiotics as follows: cefazolin 100%, ciprofloxacin 100%, ofloxacin 95.8%, kanamycin 95.8%, carbenicillin 93.7%, ticarcillin 93.7%, piperacillin 88.9%, co-trimoxazole 79.1%, ceftizoxime 75%, gentamicin 70.8%, cefalotin 60.4%, amikacin 52% and imipenem 14.6%. Fennel essential oil possessed antibacterial effect against all isolates of A. baumannii. These results suggest the potential use of the Fennel essential oil for the control of multi-drug resistant A. baumannii infections. However, more adequate studies must be carried out to verify the possibility of using it for fighting bacterial infections in human.

摘要

本研究的目的是评估茴香精油对鲍曼不动杆菌分离株的抗菌活性。2006年4月至9月期间，从伊朗德黑兰医院烧伤病房的临床标本中收集了48株分离株。采用肉汤微量稀释法测定分离株的敏感性。测定了分离株对茴香精油的最低抑菌浓度（MIC）和最低杀菌浓度（MBC）。采用琼脂纸片扩散法检测分离株对不同抗生素的敏感性。分离株对以下抗生素的耐药率如下：头孢唑林100%、环丙沙星100%、氧氟沙星95.8%、卡那霉素95.8%、羧苄西林93.7%、替卡西林93.7%、哌拉西林88.9%、复方新诺明79.1%、头孢唑肟75%、庆大霉素70.8%、头孢噻吩60.4%、阿米卡星52%和亚胺培南14.6%。茴香精油对所有鲍曼不动杆菌分离株均具有抗菌作用。这些结果表明茴香精油在控制多重耐药鲍曼不动杆菌感染方面具有潜在用途。然而，必须进行更充分的研究以验证其用于对抗人类细菌感染的可能性。