Li Lingbing, Wei Pei, Liu Junyi
Department of Pharmaceutics, Shandong University, Jinan 250012, China.
Sheng Wu Yi Xue Gong Cheng Xue Za Zhi. 2009 Jun;26(3):526-9.
Multi-compartment linear circulation mathematical model for targeted drug delivery systems was established on the bases of compartment theory and mass conservation theory. The function formulas of drug concentration-time in blood and target organ were established. According to this model, the drug concentration-time curve for the target organ can be plotted with reference to the data on blood. Based on the target organ drug concentration-time curve,the pharmacokinetics parameters of the target organ can also be calculated by the statistical moment. We further detected the practicability of the models by using the experimental data of drug concentration-time curve in blood and target organ of microspheres. The drug concentration-time curve in blood and in target organ predicted by mathematical model was agreed with that observed.
基于房室理论和质量守恒理论，建立了靶向给药系统的多房室线性循环数学模型。建立了血液和靶器官中药物浓度-时间的函数公式。根据该模型，可参照血液数据绘制靶器官的药物浓度-时间曲线。基于靶器官药物浓度-时间曲线，还可通过统计矩计算靶器官的药代动力学参数。我们利用微球血液和靶器官药物浓度-时间曲线的实验数据进一步检测了模型的实用性。数学模型预测的血液和靶器官药物浓度-时间曲线与观察到的曲线一致。
