一种难治性慢性淋巴细胞白血病的动物模型。

An animal model for intractable chronic lymphocytic leukemia.

作者信息

Schrek R

机构信息

Research Service, Veterans Administration Hospital, Hines IL.

出版信息

Med Hypotheses. 1990 Nov;33(3):175-6. doi: 10.1016/0306-9877(90)90171-a.

DOI:10.1016/0306-9877(90)90171-a

PMID:1963468

Abstract

Lymphomas developed in mice treated with X-irradiation. The radiosensitivity of cells of the lymphomas had a bimodal frequency distribution. The cells of 11 lymphomas had approximately the same radiosensitivity as normal murine lymphocytes; 6 lymphomas were highly radioresistant. Radioresistant and radiosensitive lymphomas were analogous to intractable chronic lymphocytic leukemia (CLL) and to responsive CLL in humans. The radioresistant lymphomas can be used to study the effect of therapeutic agents on the animal model for intractable CLL both in vitro and in vivo.

摘要

用X射线照射处理的小鼠发生了淋巴瘤。淋巴瘤细胞的放射敏感性具有双峰频率分布。11个淋巴瘤的细胞与正常小鼠淋巴细胞的放射敏感性大致相同；6个淋巴瘤具有高度放射抗性。放射抗性和放射敏感性淋巴瘤分别类似于人类难治性慢性淋巴细胞白血病（CLL）和反应性CLL。放射抗性淋巴瘤可用于在体外和体内研究治疗剂对难治性CLL动物模型的作用。