Schrek R, Best W R, Stefani S
Research Service, Veterans Administration Hospital, Hines, Ill.
Acta Haematol. 1988;80(3):129-33. doi: 10.1159/000205618.
A significant positive correlation was obtained between the in vitro radiosensitivity of the blood lymphocytes of patients with chronic lymphocytic leukemia (CLL) and the in vivo response of the total leukocyte count subsequent to radiation therapy. Four types of equations were used to represent and measure the effect of in vitro X-irradiation on lymphocytes from CLL patients and measure the response of patients to a course of radiotherapy. For the in vivo analysis we used data from 10 patients who were routinely treated with a total of 16 courses of radiation therapy. The total leukocyte count showed a uniform exponential decline during a course of therapy. According to the literature, about 25% of all CLL patients and about 50% of CLL patients with advanced disease are resistant to chemotherapy. The equations and indices of the present study may be useful to diagnose CLL patients who are prone to be resistant to chemotherapy.
慢性淋巴细胞白血病（CLL）患者血液淋巴细胞的体外放射敏感性与放疗后体内白细胞总数的反应之间存在显著正相关。使用了四种类型的方程来表示和测量体外X射线照射对CLL患者淋巴细胞的影响，并测量患者对一个疗程放疗的反应。对于体内分析，我们使用了10例患者的数据，这些患者常规接受了总共16个疗程的放射治疗。在一个疗程的治疗期间，白细胞总数呈均匀指数下降。根据文献，所有CLL患者中约25%以及晚期CLL患者中约50%对化疗耐药。本研究的方程和指标可能有助于诊断易于对化疗耐药的CLL患者。
