Debeljuk L, Villanúa M A, Bartke A
Department of Physiology, Southern Illinois University School of Medicine, Carbondale 62901.
Neurosci Lett. 1990 Dec 11;120(2):253-5. doi: 10.1016/0304-3940(90)90052-b.
The fluctuations in the neurokinin A concentrations in the hypothalamus and anterior pituitary of female golden hamsters were studied in the different stages of the estrous cycle, and they were correlated with the changes in serum estradiol levels. Neurokinin A levels in the hypothalamus were lowest at day 4 of the cycle (proestrus), when serum estradiol levels were highest. Neurokinin A levels in the hypothalamus of hamsters in day 1 (estrus), day 2 (diestrus I), and day 3 (diestrus II) were not significantly different from each other. In the anterior pituitary, the highest neurokinin A concentrations were found during day 1 of the cycle (estrus), the levels in day 2 (diestrus I), day 3 (diestrus II), and day 4 (proestrus) were significantly lower than at estrus, again showing the lowest levels during proestrus, when estradiol levels were maximal. These results show that neurokinin A levels in the hypothalamus and anterior pituitary of the female hamster undergo significant changes during the estrous cycle.
研究了雌性金黄地鼠发情周期不同阶段下丘脑和垂体前叶中神经激肽A浓度的波动情况，并将其与血清雌二醇水平的变化进行关联。在周期的第4天（动情前期），下丘脑的神经激肽A水平最低，此时血清雌二醇水平最高。第1天（发情期）、第2天（动情间期I）和第3天（动情间期II）仓鼠下丘脑的神经激肽A水平彼此无显著差异。在垂体前叶，周期第1天（发情期）神经激肽A浓度最高，第2天（动情间期I）、第3天（动情间期II）和第4天（动情前期）的水平显著低于发情期，再次显示在动情前期水平最低，此时雌二醇水平最高。这些结果表明，雌性仓鼠下丘脑和垂体前叶中的神经激肽A水平在发情周期中发生显著变化。
