Jonkman Sietse, Mar Adam C, Dickinson Anthony, Robbins Trevor W, Everitt Barry J
Behavioural and Clinical Neuroscience Institute and Department of Experimental Psychology, University of Cambridge, Downing Street, Cambridge CB2 3EB, United Kingdom.
Behav Neurosci. 2009 Aug;123(4):875-85. doi: 10.1037/a0016330.
The potential role of the prelimbic cortex of the rat in the acquisition of instrumental responding is currently uncertain. In addition, modeling the acquisition of Pavlovian and spatial conditioning tasks has suggested that the process of acquisition can, for certain forms of learning, be step like and consequently misrepresented in averaged group curves. Here, the authors report an experiment investigating the potential involvement of the prelimbic cortex in instrumental acquisition, in which the authors used the control data to model individual acquisition curves mathematically. The authors show that instrumental acquisition under fixed interval schedules was a gradual process extending over 4 instrumental sessions that is well represented in averaged group curves. Postsession infusion of a protein synthesis inhibitor into the prelimbic cortex did not affect any measure of acquisition, showing that during acquisition the prelimbic cortex does not mediate postsession consolidation of instrumental learning. However, inactivation of the prelimbic cortex increased responding, suggesting that the prelimbic cortex mediates a form of inhibitory response control.
大鼠前边缘皮层在工具性反应习得中的潜在作用目前尚不确定。此外，对经典条件反射和空间条件任务习得的建模表明，对于某些形式的学习，习得过程可能是阶段性的，因此在平均组曲线中会被错误呈现。在此，作者报告了一项研究前边缘皮层在工具性习得中潜在参与情况的实验，其中作者使用对照数据对个体习得曲线进行数学建模。作者表明，在固定间隔时间表下的工具性习得是一个逐渐展开的过程，跨越4个工具性训练阶段，这在平均组曲线中得到了很好的体现。在训练后向前边缘皮层注入蛋白质合成抑制剂并未影响任何习得指标，表明在习得过程中，前边缘皮层并不介导工具性学习的训练后巩固。然而，前边缘皮层的失活增加了反应，这表明前边缘皮层介导了一种抑制性反应控制形式。
