He K, Liou H Q
Daping Hospital, Third Military Medical College, Chongqing.
Sheng Li Xue Bao. 1990 Dec;42(6):591-4.
The effect of endotoxin on human platelet was studied in vitro. E Coli O55B5 endotoxin inhibited spontaneous platelet aggregation but had no effect on platelet aggregation by epinephrine and the release of contents from dense granule, alpha-granule of platelet. The endotoxin also elevated cAMP and increased the activity of calmodulin in platelet, which might account for the effect of the endotoxin on platelet. In addition, a reduced concentration of 5-HT in the supernate of endotoxin group was also observed.
在体外研究了内毒素对人血小板的作用。大肠杆菌O55B5内毒素抑制血小板的自发聚集，但对肾上腺素诱导的血小板聚集以及血小板致密颗粒、α颗粒内容物的释放没有影响。内毒素还能提高血小板中cAMP的水平并增加钙调蛋白的活性，这可能是内毒素对血小板产生作用的原因。此外，还观察到内毒素组上清液中5-羟色胺浓度降低。
