布洛芬和萘普生氨基酰基、二肽基及酯衍生物的简便合成
Convenient synthesis of Ibuprofen and naproxen aminoacyl, dipeptidoyl and ester derivatives.
作者信息
Katritzky Alan R, Jishkariani Davit, Narindoshvili Tamari
机构信息
Center for Heterocyclic Compounds, Department of Chemistry, University of Florida, Gainesville, FL 32611-7200, USA.
出版信息
Chem Biol Drug Des. 2009 Jun;73(6):618-26. doi: 10.1111/j.1747-0285.2009.00811.x.
Abstract
DL-Ibuprofen and L-naproxen were coupled with amino acids and other bioactive compounds to provide ibuprofen and naproxen bioconjugates in 61-95% yield as prodrugs or potential drug candidates.
摘要
将DL-布洛芬和L-萘普生与氨基酸及其他生物活性化合物偶联，以61 - 95%的产率得到布洛芬和萘普生生物共轭物，作为前药或潜在的药物候选物。
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