Jiang Jian-xin, Li Li
State Key Laboratory of Trauma, Burns and Combined Injury, Institute of Surgery Research, Third Military Medical University, Chongqing, China.
Chin J Traumatol. 2009 Aug;12(4):228-33.
Acute respiratory distress syndrome (ARDS) remains a poor prognosis in spite of the recent development of new therapeutic strategies. Cell-based therapy with stem cells has been considered as a promising way for the treatment of vital organ damage. Putative endogenous stem cells have been shown to be located within the adult lung in the basal layer of the upper airways, within or near pulmonary neuroendocrine cell rests, at the bronchoalveolar junction, as well as within the alveolar epithelium. These stem cells are hypothesized to be the source of lung regeneration and repair. But this mechanism seems to be insufficient after lung injury. There is increasing excitement over the last few years with the suggestion that exogenous stem cells may offer new treatment options for ARDS. Exogenous stem cells have the ability to differentiate and function as both airway and lung parenchymal epithelial cells in both in vitro and increasingly in vivo experiments. However, there is great controversy concerning the repair effect of adult stem cells in lung injury. This review evaluates the advances in endogenous respiratory stem cells, and assesses the evidence for the use of stem cells in the repair of lung injury.
尽管近年来新的治疗策略不断发展，但急性呼吸窘迫综合征（ARDS）的预后仍然很差。基于细胞的干细胞治疗被认为是治疗重要器官损伤的一种有前景的方法。据推测，内源性干细胞位于成人肺部上呼吸道的基底层、肺神经内分泌细胞巢内或其附近、支气管肺泡交界处以及肺泡上皮内。这些干细胞被认为是肺再生和修复的来源。但在肺损伤后，这种机制似乎并不充分。在过去几年里，越来越多的人兴奋地认为，外源性干细胞可能为ARDS提供新的治疗选择。在体外实验以及越来越多的体内实验中，外源性干细胞都有分化并发挥气道和肺实质上皮细胞功能的能力。然而，关于成体干细胞在肺损伤修复中的作用存在很大争议。本综述评估了内源性呼吸干细胞的研究进展，并评估了使用干细胞修复肺损伤的证据。
