涉及与食物动机相关的努力方面的多巴胺/腺苷相互作用。
Dopamine/adenosine interactions involved in effort-related aspects of food motivation.
机构信息
Dept. of Psychology, University of Connecticut, Storrs, CT 06269-1020, USA.
出版信息
Appetite. 2009 Dec;53(3):422-5. doi: 10.1016/j.appet.2009.07.018. Epub 2009 Jul 25.
Abstract
Nucleus accumbens dopamine (DA) is involved in effort-related aspects of food motivation. Accumbens DA depletions reduce the tendency of rats to work for food, and alter effort-related choice, but leave other aspects of food motivation and appetite intact. DA and adenosine receptors interact to regulate effort-related processes. Adenosine A(2A) antagonists can reverse the effects of DA D(2) antagonists on effort-related choice, and intra-accumbens injections of a adenosine A(2A) agonist produce effects that are similar to those produced by accumbens DA depletion or antagonism. These studies have implications for understanding the neurochemical interactions that underlie activational aspects of motivation.
摘要
伏隔核多巴胺（DA）参与与努力相关的食物动机方面。伏隔核 DA 的耗竭会降低老鼠为食物而工作的倾向，并改变与努力相关的选择，但不影响其他方面的食物动机和食欲。DA 和腺苷受体相互作用以调节与努力相关的过程。腺苷 A（2A）拮抗剂可以逆转 DA D（2）拮抗剂对与努力相关的选择的影响，而伏隔核内注射 a 腺苷 A（2A）激动剂产生的效果类似于伏隔核 DA 耗竭或拮抗产生的效果。这些研究对于理解激活动机的神经化学相互作用具有重要意义。
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