蒙古儿童中的甲型和戊型肝炎病毒感染

Hepatitis A and E virus infections among children in Mongolia.

作者信息

Davaalkham Dambadarjaa, Enkhoyun Tsogzolbaatar, Takahashi Masaharu, Nakamura Yosikazu, Okamoto Hiroaki

机构信息

Department of Epidemiology and Biostatistics, School of Public Health, Health Sciences University of Mongolia, Ulaanbaatar, Mongolia.

出版信息

Am J Trop Med Hyg. 2009 Aug;81(2):248-51.

PMID:19635878

Abstract

To compare the epidemiologic profiles of hepatitis A virus (HAV) and hepatitis E virus (HEV) infections in children in Mongolia, the prevalence of HAV and HEV infections was studied serologically and molecularly among 520 apparently healthy children 7-12 years of age (mean +/- standard deviation, 8.5 +/- 0.8 years) using serum samples obtained in 2004. Total antibody against HAV (anti-HAV) was detected in 438 children (84.2%), whereas IgG antibody against HEV (anti-HEV IgG) was detected in only three subjects (0.6%). All three subjects with anti-HEV IgG were negative for anti-HEV IgM and HEV RNA. The presence of HAV RNA was tested in all 520 subjects, and one child (9-year-old girl) was found to have detectable HAV RNA (subgenotype IA). In conclusion, HEV infection was uncommon, but subclinical HAV infection was highly prevalent among children in Mongolia.

摘要

为比较蒙古儿童甲型肝炎病毒（HAV）和戊型肝炎病毒（HEV）感染的流行病学特征，2004年我们利用血清样本，对520名7至12岁（平均±标准差，8.5±0.8岁）的表面健康儿童进行了HAV和HEV感染患病率的血清学及分子学研究。438名儿童（84.2%）检测到抗HAV总抗体（抗-HAV），而仅3名受试者（0.6%）检测到抗HEV IgG抗体。所有3名抗HEV IgG受试者的抗HEV IgM和HEV RNA均为阴性。对所有520名受试者检测HAV RNA，发现1名儿童（9岁女孩）可检测到HAV RNA（IA亚基因型）。总之，HEV感染不常见，但蒙古儿童中HAV亚临床感染非常普遍。