Tsatsralt-Od Bira, Takahashi Masaharu, Endo Kazunori, Agiimaa Dondog, Buyankhuu Osorjin, Okamoto Hiroaki
Division of Virology, Department of Infection and Immunity, Jichi Medical University School of Medicine, Tochigi-Ken, Japan.
J Med Virol. 2007 Jan;79(1):18-25. doi: 10.1002/jmv.20758.
To compare the epidemiologic profiles of hepatitis A virus (HAV) and hepatitis E virus (HEV) infections in children in Mongolia, the prevalence of HAV and HEV infections was investigated serologically and molecularly among 717 apparently healthy individuals of 0-20 years of age (mean +/- standard deviation, 8.6 +/- 4.9 years) using serum samples obtained between October 2005 and January 2006. Total antibody against HAV (anti-HAV [total]) was detected in 494 (68.9%) of the 717 subjects, while IgG antibody against HEV (anti-HEV IgG) was detected in only five subjects (0.7%) (P < 0.0001). All five subjects who had anti-HEV IgG, were negative for anti-HEV IgM and HEV RNA. Anti-HAV was detectable in 24 (75.0%) of the 32 infants aged 7 days to 6 months, but not in any of the 8 infants aged 7 to <12 months. The prevalence of anti-HAV was 19.5% (17/87) in the age group of 1-3 years, and it increased to 50.0% (69/138) in the age group of 4-6 years, and further to 81.4% (105/129) in the age group of 7-9 years. Of note, 97.2% of the subjects in the age group of 16-20 years had anti-HAV. The presence of HAV RNA was tested in all 717 subjects, and three children of 1, 4, or 8 years of age were found to have detectable HAV RNA (subgenotype IA). No subject had a history of hepatitis or jaundice. In conclusion, HEV infection was uncommon, but HAV infection lacking overt clinical features was prevalent among children in Mongolia.
为比较蒙古儿童甲型肝炎病毒（HAV）和戊型肝炎病毒（HEV）感染的流行病学特征，于2005年10月至2006年1月期间，采用血清样本，对717名年龄在0至20岁（平均±标准差，8.6±4.9岁）的表面健康个体进行了HAV和HEV感染患病率的血清学及分子学调查。717名受试者中，494名（68.9%）检测到抗HAV总抗体（抗-HAV[总]），而仅5名受试者（0.7%）检测到抗HEV IgG抗体（P<0.0001）。所有5名抗HEV IgG阳性的受试者，抗HEV IgM和HEV RNA均为阴性。32名7天至6个月龄婴儿中，24名（75.0%）可检测到抗-HAV，但8名7至<12个月龄婴儿中无一例可检测到。1至3岁年龄组抗-HAV患病率为19.5%（17/87），4至6岁年龄组增至50.0%（69/138），7至9岁年龄组进一步增至81.4%（105/129）。值得注意的是，16至20岁年龄组中97.2%的受试者有抗-HAV。对所有717名受试者检测了HAV RNA，发现3名1岁、4岁或8岁儿童可检测到HAV RNA（IA亚基因型）。所有受试者均无肝炎或黄疸病史。总之，HEV感染不常见，但蒙古儿童中缺乏明显临床特征的HAV感染很普遍。
