血液系统疾病脾切除术后的血管并发症。
Vascular complications after splenectomy for hematologic disorders.
作者信息
Crary Shelley E, Buchanan George R
机构信息
Department of Pediatrics, University of Texas Southwestern Medical Center at Dallas, TX 75390, USA.
出版信息
Blood. 2009 Oct 1;114(14):2861-8. doi: 10.1182/blood-2009-04-210112. Epub 2009 Jul 27.
Abstract
The most widely recognized long-term risk of splenectomy is overwhelming bacterial infection. More recently, thrombosis has become appreciated as another potential complication of the procedure. Because of these long-term risks, the indications for and timing of splenectomy are debated in the medical community. Accordingly, the adverse effects and benefits of splenectomy for hematologic disorders and other conditions demand further study. This comprehensive review summarizes the existing literature pertaining to vascular complications after splenectomy for hematologic conditions and attempts to define the potential pathophysiologic mechanisms involved. This complex topic encompasses diverse underlying conditions for which splenectomy is performed, diverse thrombotic complications, and multiple pathophysiologic mechanisms.
摘要
脾切除术后最广为人知的长期风险是暴发性细菌感染。最近，血栓形成已被视为该手术的另一种潜在并发症。由于这些长期风险，医学界对脾切除术的适应症和时机存在争议。因此，脾切除术治疗血液系统疾病和其他病症的不良反应和益处需要进一步研究。这篇综述总结了有关血液系统疾病脾切除术后血管并发症的现有文献，并试图确定其中潜在的病理生理机制。这个复杂的主题涵盖了进行脾切除术的各种潜在病症、各种血栓形成并发症以及多种病理生理机制。
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Vascular complications after splenectomy for hematologic disorders.血液系统疾病脾切除术后的血管并发症。
Blood. 2009 Oct 1;114(14):2861-8. doi: 10.1182/blood-2009-04-210112. Epub 2009 Jul 27.
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