Nonclinical Development and Applied Biology, Emisphere Technologies, 240 Cedar Knolls Rd, Cedar Knolls, NJ 07929, USA.
Int J Toxicol. 2009 Jul-Aug;28(4):266-77. doi: 10.1177/1091581809337736.
Salcaprozate sodium (SNAC) (sodium 8-((2-hydroxybenzoyl) amino) octanoate, CAS RN 203787-91-1) is classified as an oral absorption promoter and may be a useful means for improving the absorption of certain nutrients and pharmaceutical agents. Presented herein is a subset of data from a larger study evaluating the potential effects of SNAC on the gestation, parturition, lactation, maternal behavior, and offspring development of rats. Pregnant Crl:CD BR VAF/Plus female rats (F(0); n = 25) received SNAC at 1000 mg/kg/d orally (gavage) from implantation through lactation and weaning. F(1) pups were exposed in utero and potentially through maternal milk; observations continued through sexual maturity. The study concluded with Caesarean sectioning of F(1) dams for litter observations and fetal evaluations. No deaths, abortions, premature deliveries, or gross lesions occurred in (F(0)) dams. Excess salivation, red perivaginal substance, and slight reductions in body weights, body weight gains, and/or feed intake were noted in late gestation/early lactation. SNAC was associated with a prolonged gestation period, leading to a greater number of dams with stillborn pups, higher number of stillborn pups, and reduced live litter size. Offspring body weights/gains, feed consumption, age of sexual maturation, mating, fertility, behavioral parameters, and organ weights at necropsy were unaffected by SNAC. No gross external changes were observed in F(1) or F(2) pups. In summary, SNAC administered orally at 1000 mg/kg/d to pregnant rats from gestation to weaning resulted in a slight decrease in maternal body weights (-3.8%) and prolonged gestation, along with an increase in stillbirths, but had no effects on growth and development in surviving offspring.
苯甲酸钠（SNAC）（8-（2-羟基苯甲酰基）氨基辛酸钠，CAS RN 203787-91-1）被归类为口服吸收促进剂，可能是改善某些营养物质和药物吸收的有用手段。本文介绍了一项更大规模研究的部分数据，该研究评估了 SNAC 对大鼠妊娠、分娩、泌乳、母性行为和后代发育的潜在影响。怀孕的 Crl：CD BR VAF/Plus 雌性大鼠（F(0)；n = 25）从植入到哺乳期和断奶期间每天口服 1000 mg/kg 的 SNAC（灌胃）。F(1)幼仔在子宫内和通过母乳暴露；观察持续到性成熟。该研究以剖宫产 F(1) 代孕母鼠进行产仔观察和胎儿评估结束。（F(0)）代孕母鼠未发生死亡、流产、早产或明显病变。在妊娠晚期/泌乳早期观察到唾液分泌过多、阴道周围有红色物质、体重、体重增加和/或采食量轻微减少。SNAC 与妊娠期延长有关，导致更多的死胎、更多的死胎和活产仔数减少。后代体重/增重、饲料消耗、性成熟年龄、交配、生育能力、行为参数和尸检时的器官重量不受 SNAC 影响。F(1)或 F(2)幼仔未观察到明显的外部变化。总之，妊娠大鼠从妊娠到断奶期间每天口服 1000mg/kg 的 SNAC 导致母体体重轻微下降（-3.8%）和妊娠期延长，死胎增加，但对存活后代的生长发育没有影响。
