Aspects of the control of phosphoenolpyruvate carboxykinase gene transcription.
作者信息
Yang Jianqi, Reshef Lea, Cassuto Hanoch, Aleman Gabriela, Hanson Richard W
机构信息
Department of Biochemistry, Case Western Reserve University School of Medicine, Cleveland, Ohio 44106-4936, USA.
出版信息
J Biol Chem. 2009 Oct 2;284(40):27031-5. doi: 10.1074/jbc.R109.040535. Epub 2009 Jul 27.
Abstract
摘要
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Glutamine metabolism: Role in acid-base balance*.谷氨酰胺代谢：在酸碱平衡中的作用*
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Activation of SIRT1 by resveratrol represses transcription of the gene for the cytosolic form of phosphoenolpyruvate carboxykinase (GTP) by deacetylating hepatic nuclear factor 4alpha.白藜芦醇激活SIRT1可通过使肝细胞核因子4α去乙酰化来抑制磷酸烯醇式丙酮酸羧激酶（GTP）胞质型基因的转录。
J Biol Chem. 2009 Oct 2;284(40):27042-53. doi: 10.1074/jbc.M109.047340. Epub 2009 Aug 3.
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Protein acetylation microarray reveals that NuA4 controls key metabolic target regulating gluconeogenesis.蛋白质乙酰化微阵列分析表明，NuA4控制着调节糖异生的关键代谢靶点。
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Insulin represses phosphoenolpyruvate carboxykinase gene transcription by causing the rapid disruption of an active transcription complex: a potential epigenetic effect.胰岛素通过导致活性转录复合物迅速解体来抑制磷酸烯醇式丙酮酸羧激酶基因转录：一种潜在的表观遗传效应。
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5
Synthesis and degradation of phosphoenolpyruvate carboxylase in rat liver and adipose tissue. Changes during a starvation-re-feeding cycle.磷酸烯醇丙酮酸羧激酶在大鼠肝和脂肪组织中的合成与降解。饥饿-再喂养循环期间的变化。
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Glucocorticoids regulate transcription of the gene for phosphoenolpyruvate carboxykinase in the liver via an extended glucocorticoid regulatory unit.糖皮质激素通过一个扩展的糖皮质激素调节单元来调控肝脏中磷酸烯醇式丙酮酸羧激酶基因的转录。
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Factors that control the tissue-specific transcription of the gene for phosphoenolpyruvate carboxykinase-C.控制磷酸烯醇式丙酮酸羧激酶-C基因组织特异性转录的因素。
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8
SREBP-1c and Sp1 interact to regulate transcription of the gene for phosphoenolpyruvate carboxykinase (GTP) in the liver.固醇调节元件结合蛋白-1c（SREBP-1c）与转录因子Sp1相互作用，以调控肝脏中磷酸烯醇式丙酮酸羧激酶（GTP）基因的转录。
J Biol Chem. 2004 Apr 9;279(15):15385-95. doi: 10.1074/jbc.M309905200. Epub 2004 Jan 26.
9
The transcriptional regulation of phosphoenolpyruvate carboxykinase gene in the kidney requires the HNF-1 binding site of the gene.肾脏中磷酸烯醇式丙酮酸羧激酶基因的转录调控需要该基因的肝细胞核因子-1结合位点。
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Mechanism of increased renal gene expression during metabolic acidosis.代谢性酸中毒期间肾脏基因表达增加的机制。
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