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影响钙拮抗剂组织选择性的因素。

Factors modifying the tissue selectivity of calcium-antagonists.

作者信息

Spedding M, Fraser S, Clarke B, Patmore L

机构信息

Syntex Research Centre, Riccarton, Edinburgh, United Kingdom.

出版信息

J Neural Transm Suppl. 1990;31:5-16.

PMID:1963634
Abstract

The factors modifying the tissue selectivity of calcium-antagonists are reviewed, with special reference to smooth muscle. Nicardipine was the most selective compound for the vasculature compared with the myocardium.

摘要

本文综述了影响钙拮抗剂组织选择性的因素,特别提及了平滑肌。与心肌相比,尼卡地平对血管系统具有最高的选择性。

相似文献

1
Factors modifying the tissue selectivity of calcium-antagonists.影响钙拮抗剂组织选择性的因素。
J Neural Transm Suppl. 1990;31:5-16.
2
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J Med Chem. 2004 Jan 1;47(1):254-61. doi: 10.1021/jm030333h.
3
Classification and tissue selectivity of calcium antagonists.钙拮抗剂的分类及组织选择性
Z Kardiol. 1990;79 Suppl 3:107-11.
4
[Calcium channels and calcium antagonists].[钙通道与钙拮抗剂]
Tanpakushitsu Kakusan Koso. 1988 Sep;33(12):1862-76.
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Cardiovascular characterization of pyrrolo[2,1-d][1,5]benzothiazepine derivatives binding selectively to the peripheral-type benzodiazepine receptor (PBR): from dual PBR affinity and calcium antagonist activity to novel and selective calcium entry blockers.选择性结合外周型苯二氮䓬受体(PBR)的吡咯并[2,1-d][1,5]苯并硫氮杂䓬衍生物的心血管特性:从双重PBR亲和力和钙拮抗剂活性到新型选择性钙内流阻滞剂
J Med Chem. 1996 Jul 19;39(15):2922-38. doi: 10.1021/jm960162z.
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Mechanism of action of calcium antagonists on myocardial and smooth muscle membranes.钙拮抗剂对心肌和平滑肌细胞膜的作用机制。
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[Calcium antagonists. Great tissue selectivity is the basis of their therapeutic use].
Lakartidningen. 1997 Sep 3;94(36):3024-6, 3029-31.
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[Tissue selectivity of calcium channel blockers].[钙通道阻滞剂的组织选择性]
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The 1,4-dihydropyridine receptor: a regulatory component of the Ca2+ channel.1,4-二氢吡啶受体:钙通道的一种调节成分。
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Pharmacological in vitro studies of the new 1,4-dihydropyridine calcium antagonist lercanidipine.新型1,4 - 二氢吡啶类钙拮抗剂乐卡地平的体外药理学研究
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L-type voltage-dependent calcium channels do not modulate aminergic neurotransmitter release induced by transient global cerebral ischaemia: an in vivo microdialysis study in rat.
L型电压依赖性钙通道不调节短暂性全脑缺血诱导的胺能神经递质释放:大鼠体内微透析研究
Exp Brain Res. 1993;93(2):288-92. doi: 10.1007/BF00228396.
4
Cardioselectivity of calcium antagonists.钙拮抗剂的心脏选择性
Cardiovasc Drugs Ther. 1994 May;8 Suppl 2:353-64. doi: 10.1007/BF00877320.