Cheng J T, Shen C L, Jou T C
Department of Pharmacology and Anatomy, College of Medicine, National Cheng Kung University, Tainan City, Republic of China.
Neurosci Res. 1990 Dec;9(3):202-7. doi: 10.1016/0168-0102(90)90005-y.
In the striatal homogenates of rats, octopamine produced a dose-dependent inhibition of dopamine D-1 receptor both in the receptor binding of [3H]Sch-23390 and the formation of cyclic adenosine 3',5'-monophosphate (cyclic AMP) stimulated by dopamine in the presence of sulpiride. Failure of octopamine in the displacement of binding with [3H]N-0437, one of the radioligands for the dopamine D-2 receptor, indicated the specific selectivity of octopamine to dopamine D-1 receptor sites. Lack of effect on forskolin-stimulated formation of cyclic AMP ruled out the possible direct effect of octopamine on adenylate cyclase. These results suggest that octopamine possesses the ability to bind to striatal dopamine D-1 receptors of rats.
在大鼠的纹状体匀浆中，章鱼胺对多巴胺D-1受体产生剂量依赖性抑制作用，这体现在[3H]Sch-23390的受体结合以及在舒必利存在下多巴胺刺激的环磷腺苷（cAMP）形成过程中。章鱼胺不能置换多巴胺D-2受体的放射性配体之一[3H]N-0437的结合，这表明章鱼胺对多巴胺D-1受体位点具有特异性选择性。章鱼胺对福斯高林刺激的cAMP形成没有影响，排除了章鱼胺对腺苷酸环化酶可能的直接作用。这些结果表明章鱼胺具有与大鼠纹状体多巴胺D-1受体结合的能力。
