MESD蛋白保守区域MESD(12 - 155)的完整核磁共振光谱归属。

A complete NMR spectral assignment of the conserved region of the MESD protein, MESD(12-155).

作者信息

Chen Jianglei, Bu Guojun, Wang Jianjun

机构信息

Department of Biochemistry and Molecular Biology, School of Medicine, Wayne State University, Detroit, MI 48201, USA.

出版信息

Biomol NMR Assign. 2007 Jul;1(1):3-5. doi: 10.1007/s12104-007-9003-6. Epub 2007 May 22.

DOI:10.1007/s12104-007-9003-6

PMID:19636811

Abstract

The low-density lipoprotein (LDL) receptor family members control diverse developmental and physiological pathways. Mesoderm development (MESD) protein is a 195-residue protein that functions as a specialized molecular chaperone to promote the proper folding of the six-bladed beta-propeller/EGF modules of the LDL receptor family members. Here we report a complete NMR spectral assignment of the most conserved region of MESD protein, MESD(12-155).

摘要

低密度脂蛋白（LDL）受体家族成员控制着多种发育和生理途径。中胚层发育（MESD）蛋白是一种由195个氨基酸残基组成的蛋白质，作为一种特殊的分子伴侣，促进LDL受体家族成员的六叶β-螺旋桨/表皮生长因子（EGF）模块正确折叠。在此，我们报道了MESD蛋白最保守区域MESD(12 - 155)的完整核磁共振（NMR）光谱归属。