无脂质小鼠载脂蛋白A-I（apoAI）C末端截短突变体apoAI(1-216)的完整核磁共振光谱归属
A complete NMR spectral assignment of the lipid-free mouse apolipoprotein A-I (apoAI) C-terminal truncation mutant, apoAI(1-216).
作者信息
Yang Yunhuang, Hoyt David, Wang Jianjun
机构信息
Department of Biochemistry and Molecular Biology, School of Medicine, Wayne State University, Detroit, MI 48201, USA.
出版信息
Biomol NMR Assign. 2007 Jul;1(1):109-11. doi: 10.1007/s12104-007-9031-2. Epub 2007 Jul 28.
ApoAI is the major protein component of the high-density lipoprotein (HDL) that has been a hot subject of interests because of its anti-atherogenic properties. Lipid-free apoAI specifically binds to phospholipids, triggering HDL formation. Here we report a complete backbone assignment and nearly complete sidechain assignment of a C-terminal 24-residue truncation mutant of mouse apoAI, apoAI(1-216), in its lipid-free form.
载脂蛋白AI（ApoAI）是高密度脂蛋白（HDL）的主要蛋白质成分，因其抗动脉粥样硬化特性而一直是研究热点。无脂质的ApoAI能特异性结合磷脂，引发HDL的形成。在此，我们报告了小鼠ApoAI的C端24个残基截短突变体apoAI(1 - 216)无脂质形式的完整主链归属和几乎完整的侧链归属。
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