Deshmukh Mandar V, Oku Yuko, Gross John D
Department Pharmaceutical Chemistry, University of California San Francisco, 600 16th Street, S-512E, Box 2280, San Francisco, CA 94158, USA.
Biomol NMR Assign. 2007 Jul;1(1):17-8. doi: 10.1007/s12104-007-9023-2. Epub 2007 Jul 21.
Eukaryotic mRNA decapping by Dcp2 is the penultimate step in several mRNA decay pathways. To understand regulation of Dcp2 by ligand interactions, we have assigned the backbone and sidechain methyl Ile (delta1), Leu and Val chemical shifts of the catalytic domain of the S. Cerevisiae enzyme.
真核生物中由Dcp2介导的mRNA去帽是几种mRNA降解途径中的倒数第二步。为了了解配体相互作用对Dcp2的调控，我们已确定了酿酒酵母酶催化结构域的主链以及侧链甲基异亮氨酸（δ1）、亮氨酸和缬氨酸的化学位移。
