恶性疟原虫FKBP35的FK506结合结构域的1H、13C和15N共振归属
1H, 13C, and 15N resonance assignments of FK506-binding domain of Plasmodium falciparum FKBP35.
作者信息
Kang Cong Bao, Ye Hong, Yoon Hye Rim, Yoon Ho Sup
机构信息
School of Biological Science, Nanyang Technological University, 60 Nanyang Drive, Singapore 637665, Singapore.
出版信息
Biomol NMR Assign. 2007 Jul;1(1):27-8. doi: 10.1007/s12104-007-9005-4. Epub 2007 May 5.
PMID:19636818
Abstract
The immunosuppressant FK506 binds Plasmodium falciparum FK-506 binding protein 35 (PfFKBP35) and shows anti-malarial activity. To understand molecular mechanism of the drug on the parasite, we have done NMR studies. Here, we report the assignment of FK506-binding domain of PfFKBP35.
摘要
免疫抑制剂FK506可结合恶性疟原虫FK-506结合蛋白35（PfFKBP35）并显示出抗疟活性。为了解该药物对疟原虫的分子作用机制，我们进行了核磁共振研究。在此，我们报告PfFKBP35的FK506结合结构域的归属。
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