Terrien Elouan, Simenel Catherine, Prehaud Christophe, Buc Henri, Delepierre Muriel, Lafon Monique, Wolff Nicolas
Unité de Résonance Magnétique Nucléaire des Biomolécules, Département de Biologie Structurale et Chimie, CNRS URA 2185, Institut Pasteur, 28, rue du Docteur Roux, 75724, Paris Cedex 15, France.
Biomol NMR Assign. 2009 Jun;3(1):45-8. doi: 10.1007/s12104-008-9138-0. Epub 2009 Jan 13.
Most of microbes hijack the cellular machinery to their advantage by interacting with specific target of the host cell. Glycoprotein of rabies virus is a key factor controlling the homeostasis of infected neuronal cells and proteins belonging to the human microtubule associated serine threonine kinase family have been identified as potential cellular partners. As a first step towards its structural study, we have assigned the backbone and side chain nuclei resonances of the PDZ domain (PSD-95, Discs Large, ZO-1) of MAST205 in complex with the C-terminal residues of the glycoprotein of rabies virus. The BMRB accession code is 155972.
大多数微生物通过与宿主细胞的特定靶点相互作用，将细胞机制为己所用。狂犬病病毒糖蛋白是控制受感染神经元细胞内稳态的关键因素，而属于人类微管相关丝氨酸苏氨酸激酶家族的蛋白质已被确定为潜在的细胞伴侣。作为其结构研究的第一步，我们已归属了与狂犬病病毒糖蛋白C末端残基结合的MAST205的PDZ结构域（PSD-95、盘状大蛋白、紧密连接蛋白1）的主链和侧链核共振。BMRB登录号为155972。
