Tangye Stuart G, Tarlinton David M
Immunology and Inflammation Department, Garvan Institute of Medical Research, NSW, Australia.
Eur J Immunol. 2009 Aug;39(8):2065-75. doi: 10.1002/eji.200939531.
Immunological memory is the phenomenon whereby B and T cells have the unique ability to respond with heightened kinetics and efficacy to subsequent encounter with Ag relative to the initial exposure. In this review, we examine recent developments in the phenotypic characterisation of memory B cells, with an emphasis on the definition and functional properties of memory B-cell subsets in humans. Gene expression differences are also considered in light of the unique functional and survival properties of memory B cells, and mutations that alter memory formation and function are also examined. Finally, we consider recent advances in the understanding of germinal center B-cell differentiation through analysis of transcription factor networks operating in these B cells.
免疫记忆是一种现象，即相对于初次接触抗原，B细胞和T细胞具有独特的能力，能够以更快的动力学和更高的效能对后续再次遇到的抗原作出反应。在这篇综述中，我们研究了记忆B细胞表型特征的最新进展，重点关注人类记忆B细胞亚群的定义和功能特性。还根据记忆B细胞独特的功能和存活特性考虑了基因表达差异，并研究了改变记忆形成和功能的突变。最后，我们通过分析在这些B细胞中起作用的转录因子网络来探讨生发中心B细胞分化认识方面的最新进展。
