6-氧代-2-氮杂螺[3.3]庚烷-2-羧酸叔丁酯的合成。

Synthesis of tert-butyl 6-oxo-2-azaspiro[3.3]heptane-2-carboxylate.

作者信息

Meyers Marvin J, Muizebelt Inouk, van Wiltenburg Jim, Brown David L, Thorarensen Atli

机构信息

Pfizer Global Research & Development, 700 Chesterfield Parkway West, Chesterfield, Missouri 63017, USA.

出版信息

Org Lett. 2009 Aug 20;11(16):3523-5. doi: 10.1021/ol901325s.

DOI:10.1021/ol901325s

PMID:19637855

Abstract

Two efficient and scaleable synthetic routes to previously unknown bifunctional tert-butyl 6-oxo-2-azaspiro[3.3]heptane-2-carboxylate are described. This compound and related intermediates described herein are useful for further selective derivation on the azetidine and cyclobutane rings providing a convenient entry point to novel compounds accessing chemical space complementary to piperidine ring systems.

摘要

描述了两种高效且可扩展的合成路线，用于制备此前未知的双功能叔丁基6-氧代-2-氮杂螺[3.3]庚烷-2-羧酸酯。本文所述的该化合物及相关中间体可用于在氮杂环丁烷和环丁烷环上进行进一步的选择性衍生化，为进入与哌啶环系统互补的化学空间的新型化合物提供了一个便利的切入点。