Zhang Ruirui, Wu Chuanliu, Tong Lili, Tang Bo, Xu Qing-Hua
Department of Chemistry, National University of Singapore, Singapore 117543, Singapore.
Langmuir. 2009 Sep 1;25(17):10153-8. doi: 10.1021/la902235d.
Here we report the preparation of a novel multifunctional core-shell nanocomposite material that contains a nonporous dye-doped silica core and a mesoporous silica shell containing photosensitizer molecules, hematoporphyrin (HP). This architecture allows simultaneous fluorescence imaging and photosensitization treatment. The photosensitizer molecules are covalently linked to the mesoporous silica shell and exhibit excellent photo-oxidation efficiency. The efficiency of photo-oxidation of the core-shell hybrid nanoparticles was demonstrated to be significantly improved over that in the homogeneous solution. The mesoporous silica nanovehicle acts not only as a carrier for the photosensitizers but also as a nanoreactor to facilitate the photo-oxidation reaction. The doping of fluorescence dyes into the nonporous core endows the imaging capability, which has been demonstrated with cell imaging experiments. This approach could be easily extended to conjugate other functional regents if necessary. These multifunctional nanovehicles possess unique advantages in acting as nanocarriers in photodynamic therapy to allow simultaneous high-resolution targeting and treatment.
在此，我们报告了一种新型多功能核壳纳米复合材料的制备，该材料包含无孔染料掺杂二氧化硅核以及含有光敏剂分子血卟啉（HP）的介孔二氧化硅壳。这种结构允许同时进行荧光成像和光动力治疗。光敏剂分子与介孔二氧化硅壳共价连接，并表现出优异的光氧化效率。核壳杂化纳米粒子的光氧化效率被证明比在均相溶液中显著提高。介孔二氧化硅纳米载体不仅作为光敏剂的载体，还作为促进光氧化反应的纳米反应器。将荧光染料掺杂到无孔核中赋予了成像能力，这已通过细胞成像实验得到证明。如有必要，这种方法可以很容易地扩展以结合其他功能试剂。这些多功能纳米载体在作为光动力治疗中的纳米载体方面具有独特优势，能够同时实现高分辨率靶向和治疗。
