一组依赖类固醇的重症肌无力患者中进行环孢素开放试验的结果。

Results of an open trial of cyclosporine in a group of steroido-dependent myasthenic subjects.

作者信息

Antonini G, Bove R, Filippini C, Millefiorini M

机构信息

Department of Neuroscience, University of Rome, La Sapienza, Italy.

出版信息

Clin Neurol Neurosurg. 1990;92(4):317-21. doi: 10.1016/0303-8467(90)90057-c.

DOI:10.1016/0303-8467(90)90057-c

PMID:1963821

Abstract

9 subjects with myasthenia gravis, chronically treated with prednisone, underwent an open clinical trial with cyclosporine, an immunosuppressive and immunomodulator drug. Preliminary results after one year of treatment show that cyclosporine induces a further improvement of myasthenic symptoms, and that prednisone may be reduced or discontinued without relapse of clinical symptoms. Side effects of cyclosporine are very frequent and largely influence the treatment.

摘要

9名长期接受泼尼松治疗的重症肌无力患者参与了一项使用免疫抑制和免疫调节药物环孢素的开放临床试验。治疗一年后的初步结果显示，环孢素可进一步改善肌无力症状，且可以减少或停用泼尼松而不出现临床症状复发。环孢素的副作用非常常见，且在很大程度上影响治疗。