Inta Dragos, Trusel Massimo, Riva Marco A, Sprengel Rolf, Gass Peter
Central Institute of Mental Health Mannheim (ZI), University of Heidelberg, Germany.
Int J Neuropsychopharmacol. 2009 Sep;12(8):1133-6. doi: 10.1017/S1461145709990319. Epub 2009 Jul 29.
Preclinical and clinical studies have shown that N-methyl-D-aspartate (NMDA) receptor antagonists can exert antidepressant effects. Thus, a single intravenous injection of ketamine, a non-competitive NMDA receptor antagonists, has been recently demonstrated to produce a rapid and relatively sustained antidepressant effect in patients. Therefore, the role of NMDA receptors and their signalling pathways for pathophysiology and therapy of depression are under intense research.
临床前和临床研究表明，N-甲基-D-天冬氨酸（NMDA）受体拮抗剂可发挥抗抑郁作用。因此，最近已证实，单次静脉注射氯胺酮（一种非竞争性NMDA受体拮抗剂）可在患者中产生快速且相对持久的抗抑郁效果。因此，NMDA受体及其信号通路在抑郁症病理生理学和治疗中的作用正在深入研究中。
