Owens M J, Edwards E, Nemeroff C B
Department of Pharmacology, Duke University Medical Center, Durham, NC 27710.
Eur J Pharmacol. 1990 Nov 6;190(1-2):113-22. doi: 10.1016/0014-2999(90)94118-h.
Corticotropin-releasing factor (CRF) is the major physiological regulator of the hypothalamo-pituitary-adrenal axis. There is evidence that CRF release from the hypothalamus is under stimulatory serotonergic control. The specific 5-HT receptor subtypes that mediate this effect is unclear. Administration of the 5-HT1A agonists, 8-OH-DPAT (1 mg/kg) and ipsapirone (4 mg/kg), to rats resulted in activation of the HPA axis as evidenced by increased plasma ACTH and corticosterone concentrations in acutely treated rats and increased plasma corticosterone concentrations in both acutely and chronically treated rats. However, chronic administration of these compounds failed to alter CRF concentrations in the medium eminence or CRF receptor number of affinity in the anterior pituitary. Chronic administration of both compounds resulted in increased CRF concentrations in the piriform cortex and hippocampus, whereas 8-OH-DPAT alone increased CRF concentrations in the amygdala and entorhinal cortex. These results suggest that both hypothalamic and extrahypothalamic CRF neurons are influenced by activation of 5-HT1A receptors.
促肾上腺皮质激素释放因子（CRF）是下丘脑 - 垂体 - 肾上腺轴的主要生理调节因子。有证据表明，下丘脑释放的CRF受刺激性血清素能控制。介导这种效应的具体5 - HT受体亚型尚不清楚。给大鼠注射5 - HT1A激动剂8 - OH - DPAT（1mg/kg）和ipsapirone（4mg/kg）后，导致下丘脑 - 垂体 - 肾上腺轴激活，急性处理的大鼠血浆促肾上腺皮质激素（ACTH）和皮质酮浓度升高，急性和慢性处理的大鼠血浆皮质酮浓度均升高可证明这一点。然而，长期给予这些化合物未能改变正中隆起中的CRF浓度或垂体前叶中CRF受体的亲和力数量。长期给予这两种化合物均导致梨状皮质和海马中的CRF浓度升高，而单独给予8 - OH - DPAT则增加杏仁核和内嗅皮质中的CRF浓度。这些结果表明，下丘脑和下丘脑外的CRF神经元均受5 - HT1A受体激活的影响。
