[Selective activation of adrenaline secretion by the rat adrenal in neuroglycopenia detected via microdialysis].

Secretion of adrenaline (A) and noradrenaline (NA) was measured in conscious Wistar rats using the microdialysis probe implanted into the adrenal gland. Changes in contents of A and NA in plasma as well as in dialysate samples in response to i. v. administration of 500 mg/kg 2-deoxy-D-glucose (2-DG) were measured by HPLC with electrochemical detection. 2-DG-induced neuroglycopenia led to a selective increase in adrenal secretion of A which reached maximum 20 m after 2-DG administration, whereas an increase in A and NA contents occurred in plasma. Elevation in the plasma NA content seems to reflect an enhancement in sympathetic nervous activity.