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[类固醇结合糖蛋白在人体血液中向细胞传递激素信号的作用]

[The role of steroid-binding glycoproteins in human blood in transmitting the hormonal signal to the cell].

作者信息

Strel'chenok O A

出版信息

Fiziol Zh SSSR Im I M Sechenova. 1990 Sep;76(9):1187-96.

PMID:1963860
Abstract

The data on interaction of specific steroid-binding glycoproteins of blood plasma and of their steroid-hormone complexes with the plasma membranes of various hormone target tissues suggests that these glycoproteins play an active role in the transport of steroid hormones into the target cells. Both polypeptide and carbohydrate components of the steroid-binding glycoproteins are involved in the formation of determinants for the membrane recognition of hormone-glycoprotein complexes. This causes a modulation of the steroid hormone action on various tissues due to modifications of the glycoprotein carbohydrate structures.

摘要

关于血浆中特定类固醇结合糖蛋白及其类固醇激素复合物与各种激素靶组织的质膜相互作用的数据表明,这些糖蛋白在类固醇激素转运到靶细胞中发挥着积极作用。类固醇结合糖蛋白的多肽和碳水化合物成分都参与了激素 - 糖蛋白复合物膜识别决定簇的形成。由于糖蛋白碳水化合物结构的改变,这导致了类固醇激素对各种组织作用的调节。

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