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[性别对肝功能分化的编程与调控的激素机制]

[The hormonal mechanisms of the programming and regulation of liver function differentiation by sex].

作者信息

Rozen V B

出版信息

Fiziol Zh SSSR Im I M Sechenova. 1990 Sep;76(9):1238-44.

PMID:1963863
Abstract

Crucial role of androgens and estrogens in programming and regulation of the sex-dependent expression of a specific estrogen-binding protein, androgenous and estrogenous receptors and corticosteroid-binding globulin, was shown. Both types of the sex steroids effects were shown to be realized in the hepatocytes through respective hormonal receptors. The realization of physiological effects of the sex hormones demands the participation of STH as a permissive factor. Some theoretical and practical aspects of the sex differentiation of the liver functions, are discussed.

摘要

雄激素和雌激素在特定雌激素结合蛋白、雄激素受体和雌激素受体以及皮质类固醇结合球蛋白的性别依赖性表达的编程和调节中发挥着关键作用。两种性类固醇的作用均通过各自的激素受体在肝细胞中实现。性激素生理作用的实现需要生长激素作为允许因子的参与。本文讨论了肝功能性别分化的一些理论和实际方面。

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