[Biochemical markers of bone turnover. New aspect. Biomarkers of cartilage metabolism].

Osteoarthritis (OA) is characterized by increased cartilage degradation and wearing. The principal disease hallmarks for assessment of OA are radiographic aspects. However, laboratory markers of joint fluid, serum or urine have received growing attention in recent years. Biomarkers should be useful for improvement of diagnosis, assessment of disease progression and evaluation of therapeutic effects in OA. Here we described the outline of biomarkers in cartilage including utility and weakness.