Okano Tadashi, Koike Tatsuya
Department of Orthopaedic Surgery, Osaka City University Medical School.
Clin Calcium. 2009 Aug;19(8):1149-58.
Osteoarthritis (OA) is characterized by increased cartilage degradation and wearing. The principal disease hallmarks for assessment of OA are radiographic aspects. However, laboratory markers of joint fluid, serum or urine have received growing attention in recent years. Biomarkers should be useful for improvement of diagnosis, assessment of disease progression and evaluation of therapeutic effects in OA. Here we described the outline of biomarkers in cartilage including utility and weakness.
骨关节炎（OA）的特征是软骨降解和磨损增加。评估OA的主要疾病标志是影像学表现。然而，近年来关节液、血清或尿液的实验室标志物受到了越来越多的关注。生物标志物应有助于改善OA的诊断、疾病进展评估和治疗效果评价。在此，我们描述了软骨中生物标志物的概述，包括其效用和不足。
