L-天冬酰胺酶——抗白血病药物。
L-asparaginase--antileukemia agent.
作者信息
Bukhari S Z, Yaqub M
出版信息
J Pak Med Assoc. 1977 Jan;27(1):262-4.
PMID:19639
Abstract
This paper describes the most recent development in the field of biosynthesis of L-Asparaginase by means of various culture, purification by Column Chromatography, informations of the Catabolite repression of L-Asparaginase and its metabolism in mycobacteria. The separation, purification studies, idea about the effect of different PH on activity, quaternary structure and the effect of specific antibodies on catalytic activity of L-Asparaginase is discussed. This material shows the role of L-Asparaginase in acute lymphocytic leukemia.
摘要
本文描述了通过各种培养方式生物合成L-天冬酰胺酶领域的最新进展、柱色谱法纯化、L-天冬酰胺酶的分解代谢阻遏及其在分枝杆菌中的代谢信息。讨论了L-天冬酰胺酶的分离、纯化研究、不同pH对其活性的影响、四级结构以及特异性抗体对其催化活性的影响。本文还展示了L-天冬酰胺酶在急性淋巴细胞白血病中的作用。
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L-asparaginase--antileukemia agent.
J Pak Med Assoc. 1977 Jan;27(1):262-4.
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