Masuoka Takayoshi, Kamei Chiaki
Department of Medicinal Pharmacology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, 700-8530, Japan.
Psychopharmacology (Berl). 2009 Oct;206(2):259-65. doi: 10.1007/s00213-009-1603-7. Epub 2009 Jul 29.
Nicotine receptors in the brain are closely related with memory amelioration induced by cholinesterase inhibitors.
The present study was undertaken to clarify the role of nicotinic receptors in the ameliorative effects of cholinesterase inhibitors on scopolamine-induced memory deficit.
Drug effects were measured using an eight-arm radial maze with four arms baited. Hippocampal theta rhythm during the radial maze task was also recorded with a polygraph system using a telemetric technique.
Scopolamine (0.5 mg/kg, i.p.) caused a spatial memory deficit as well as an increase in hippocampal theta power during radial maze performance. Pilocarpine, nicotine, physostigmine, and donepezil antagonized the effects of scopolamine. The ameliorative effects of nicotine, physostigmine, and donepezil but not piocarpine on memory performance and hippocampal theta activity were reversed by mecamylamine.
These results indicate that nicotinic receptors have an essential role in the ameliorative effects of cholinesterase inhibitors in both scopolamine-induced memory deficit and the increase in hippocampal theta activity.
大脑中的尼古丁受体与胆碱酯酶抑制剂诱导的记忆改善密切相关。
本研究旨在阐明烟碱受体在胆碱酯酶抑制剂改善东莨菪碱诱导的记忆缺陷中的作用。
使用八臂放射状迷宫，其中四个臂放置诱饵来测量药物效果。在放射状迷宫任务期间，还使用遥测技术通过多导生理记录仪记录海马θ节律。
东莨菪碱（0.5mg/kg，腹腔注射）导致空间记忆缺陷以及在放射状迷宫任务期间海马θ功率增加。毛果芸香碱、尼古丁、毒扁豆碱和多奈哌齐拮抗了东莨菪碱的作用。美加明逆转了尼古丁、毒扁豆碱和多奈哌齐对记忆表现和海马θ活动的改善作用，但未逆转毛果芸香碱的作用。
这些结果表明，烟碱受体在胆碱酯酶抑制剂改善东莨菪碱诱导的记忆缺陷和海马θ活动增加中起着重要作用。
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