发作性睡病患者的基础代谢率
Basal metabolic rate in narcoleptic patients.
作者信息
Dahmen Norbert, Tonn Peter, Messroghli Leila, Ghezel-Ahmadi David, Engel Alice
机构信息
Department of Psychiatry, University of Mainz, Mainz, Germany.
出版信息
Sleep. 2009 Jul;32(7):962-4.
STUDY OBJECTIVES
We investigated basal metabolic rate (BMR) and energy expenditure (EE) in narcoleptic patients and in BMI- and age-matched controls in order to explore the hypothesis that a reduced BMR or EE plays a role in narcolepsy-associated obesity.
DESIGN
Control group design with comparison of EE and BMR. EE was determined by indirect calorimetry using the Deltatrac Metabolic Monitor system. BMR was calculated from the oxygen consumption (VO2) and the carbon dioxide consumption (VCO2) measurements after 12 hours of fasting in the morning.
PARTICIPANTS
13 narcoleptic patients and 30 controls.
RESULTS
BMR and EE were not significantly reduced when all subjects were included into the analysis. Subgroup analysis revealed that only non-obese narcoleptics, but not obese narcoleptics had reduced BMRs in comparison to the BMI matched controls.
CONCLUSION
Our study suggests that EE plays a role in narcolepsy associated obesity. We propose that narcolepsy may lead to a shift of individual BMI set points.
研究目的
我们调查了发作性睡病患者以及体重指数（BMI）和年龄匹配的对照组的基础代谢率（BMR）和能量消耗（EE），以探究BMR或EE降低在发作性睡病相关肥胖中起作用这一假设。
设计
采用对照组设计，比较EE和BMR。EE通过使用Deltatrac代谢监测系统的间接测热法测定。BMR根据早晨禁食12小时后的耗氧量（VO2）和二氧化碳消耗量（VCO2）测量值计算得出。
参与者
13名发作性睡病患者和30名对照者。
结果
当将所有受试者纳入分析时，BMR和EE没有显著降低。亚组分析显示，与BMI匹配的对照组相比，只有非肥胖发作性睡病患者的BMR降低，而肥胖发作性睡病患者则没有。
结论
我们的研究表明EE在发作性睡病相关肥胖中起作用。我们提出发作性睡病可能导致个体BMI设定点的改变。
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