Ivanov K P
Ross Fiziol Zh Im I M Sechenova. 2009 Jun;95(6):594-600.
Our previos studies revealed the phenomenon of leucocyte adhesion to microvessel walls in gradually developing brain ischemia. The problem of effect of the blood leucocyte number in the brain ischemia upon number of the adhesion acts was considered. This work attempts to solve this problem. Number of leucocytes was measured in the white rat blood after bilateral ligation of the carotid arteries and gradual increment of the brain ischemia. Simultaneously a number of leucocytes that adhered to the brain venule wall internal surface was recorded. Beginning of the ischemia was shown to quickly increase the number of leucocytes in the blood. In 2 hours, the number increased over two-fold. At this moment, the number of adhered leucocytes practically did not increase. In 3 hours, the number of the blood leucocytes started decreasing, whereas the number of the adhered leucocytes started increasing. By the 5th hour after artery ligation, the number of the blood leucocytes decreased to initial value, whereas the number of adhered leucocytes increased over 2.5-fold. The leucocytes adhesion seems to be unrelated to increase of their number in the blood. Reduction of the leucocyte amount in the blood on the 5th hour of the ischemia is associated with increase of the leucocyte adhesion acts in the brain. Reduction of the blood leucocyte number in grave ischemia of the brain might be a sign of increase of the leucocyte adhesion act number which leads to worsening of microcirculation and perishing of the organism.
我们先前的研究揭示了在逐渐发展的脑缺血中白细胞黏附于微血管壁的现象。我们考虑了脑缺血时血液中白细胞数量对黏附行为数量的影响问题。这项工作试图解决这个问题。在双侧结扎颈动脉并使脑缺血逐渐加重后，测量了白鼠血液中的白细胞数量。同时记录了黏附于脑微静脉壁内表面的白细胞数量。结果显示，缺血开始后血液中的白细胞数量迅速增加。在2小时内，数量增加了两倍多。此时，黏附的白细胞数量实际上没有增加。在3小时时，血液中的白细胞数量开始下降，而黏附的白细胞数量开始增加。到动脉结扎后第5小时，血液中的白细胞数量降至初始值，而黏附的白细胞数量增加了2.5倍多。白细胞黏附似乎与血液中白细胞数量的增加无关。缺血第5小时血液中白细胞数量的减少与脑中白细胞黏附行为的增加有关。脑严重缺血时血液中白细胞数量的减少可能是白细胞黏附行为数量增加的标志，这会导致微循环恶化和机体死亡。
