淀粉样蛋白+激活=阿尔茨海默病？
Amyloid + activation = Alzheimer's?
作者信息
Jagust William
机构信息
Helen Wills Neuroscience Institute, University of California, Berkeley, 132 Barker Hall, Berkeley, CA 94720-3190, USA.
出版信息
Neuron. 2009 Jul 30;63(2):141-3. doi: 10.1016/j.neuron.2009.07.008.
PMID:19640471
Abstract
PET imaging of Alzheimer's disease (AD) patients demonstrates Abeta-protein accumulation in a default mode network. In this issue of Neuron, Sperling and colleagues show that cognitively intact individuals with Abeta in this network fail to deactivate it during memory tasks, a finding with important implications for cognitive aging and early detection of AD.
摘要
阿尔茨海默病（AD）患者的正电子发射断层显像（PET）显示，β-淀粉样蛋白在默认模式网络中积聚。在本期《神经元》杂志中，斯珀林及其同事表明，该网络中存在β-淀粉样蛋白的认知功能正常个体在记忆任务期间无法使其失活，这一发现对认知衰老和AD的早期检测具有重要意义。
Zotero 插件