Kim Jun Hee, von Gersdorff Henrique
The Vollum Institute, Oregon Health and Science University, Portland, OR 97239, USA.
Neuron. 2009 Jul 30;63(2):143-5. doi: 10.1016/j.neuron.2009.07.006.
During prolonged stimulation, fusion of thousands of synaptic vesicles poses a challenge for the temporal and spatial coordination of exocytosis and endocytosis. In this issue of Neuron, Hosoi and colleagues reveal that Ca2+-microdomains trigger compensatory endocytosis. Block of endocytosis enhances short-term depression by delaying vesicle recruitment to docking sites on active zones.
在长时间刺激过程中，数千个突触小泡的融合对胞吐作用和胞吞作用的时空协调提出了挑战。在本期《神经元》杂志中，细井及其同事揭示，胞内钙离子微区会触发代偿性胞吞作用。阻断胞吞作用会通过延迟囊泡募集到活性区的对接位点来增强短期抑制作用。
