Department of Experimental Medicine and Pathology, II Faculty of Medicine, Sant'Andrea Hospital, University La Sapienza, Rome, Italy.
Pathol Res Pract. 2010 May 15;206(5):331-3. doi: 10.1016/j.prp.2009.06.017. Epub 2009 Jul 28.
A case of true thymic hyperplasia (TTH) associated with thymic hemorrhage (TH) was observed in a 22-year-old male patient who presented with persistent cough and thoracic pain due to an anterior mediastinal mass. The diagnosis of TTH was supported by the observation that the mediastinal mass was essentially composed of histologically normal thymic lobules with preserved cortico-medullary differentiation. The TTH tissue presented multiple areas of hemorrhage associated with the presence of large, tortuous, abnormal vessels in the thymic stroma. Foci of spindle cell proliferations resembling an epitheliod hemangioma were also seen. This finding raises the possibility that vascular malformations, perhaps due to an abnormal growth of the thymus, may be responsible for some cases of TH associated with TTH.
我们观察到一例与胸腺出血（TH）相关的真性胸腺增生（TTH），发生于一名 22 岁男性患者，因前纵隔肿块出现持续性咳嗽和胸痛。纵隔肿块主要由组织学上正常的胸腺小叶组成，保留皮质-髓质分化，这一观察结果支持 TTH 的诊断。TTH 组织存在多处出血，伴胸腺基质中存在大而扭曲的异常血管。还可见类似于上皮样血管瘤的梭形细胞增殖灶。这一发现提示血管畸形（可能由于胸腺异常生长所致）可能是某些与 TTH 相关的 TH 的原因。
