Laqueille X
Service d'addictologie, centre hospitalier Sainte-Anne, Paris cedex 14, France.
Arch Pediatr. 2009 Sep;16(9):1302-5. doi: 10.1016/j.arcped.2009.03.016. Epub 2009 Jul 28.
Links between cannabis and schizophrenic disorders are ages old. Cannabis has effects that are close to the symptoms of schizophrenia. Abuse and dependence are more frequent in schizophrenic population than in general population. This consumption is a gravity factor in terms of prognosis. It accelerates the first psychotic decompensations. Studies by cohorts of experts allow for the affirmation that cannabis is a risk factor in schizophrenic disorders, with an effect dose and depending, above all in the case of consumption before the age of 15. This observation is in line with the greatest diffusion of cannabinoid receivers in the encephalon of schizophrenic subjects and their role in cerebral maturity during puberty.
大麻与精神分裂症之间的联系由来已久。大麻的作用与精神分裂症的症状相近。精神分裂症患者群体中滥用和依赖大麻的情况比普通人群更为常见。就预后而言，这种使用是一个严重因素。它会加速首次精神病性失代偿。专家队列研究证实，大麻是精神分裂症的一个风险因素，存在影响剂量，且尤其在15岁之前开始使用的情况下影响更大。这一观察结果与精神分裂症患者大脑中大麻素受体的高度分布及其在青春期大脑成熟过程中的作用相符。
