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[兆伏级锥形束计算机断层扫描成像传递给患者的剂量]

[Dose delivered to the patient by megavoltage cone beam computed tomography imaging].

作者信息

Isambert A, Ferreira I H, Bossi A, Beaudré A, Nicula L E, Lefkopoulos D

机构信息

Service de physique médical, institut Gustave-Roussy, 94805 Villejuif, France.

出版信息

Cancer Radiother. 2009 Sep;13(5):358-64. doi: 10.1016/j.canrad.2009.05.010. Epub 2009 Jul 28.

Abstract

PURPOSE

To study the dose delivered by a megavoltage cone beam computed tomography imaging system (MVCBCT) installed on a Oncor Impression linac (Siemens).

MATERIALS AND METHODS

The acquisition of MVCBCT images was modelled in a treatment planning system by 67 photon beams (6 MV). A study was conducted to: compare the calculated and measured dose at the centre of a cylindrical phantom; compare the calculated and measured dose distributions in the Alderson-Rando phantom (pelvis); study the influence of MVCBCT image acquisition for the repositioning of a prostate cancer patient treated by 3D conformal radiotherapy (prescribed dose of 74 Gy), on the dose-volume histograms (DVH) for the treatment plus seven MVCBCT (protocol D1-3 and weekly), treatment plus 37 MVCBCT (one for each day of treatment).

RESULTS

The difference between calculated and measured doses at the centre of the cylindrical phantom was less than 3%. A deviation of 7% maximum was found between the dose distribution calculated in the Rando phantom and the measured doses normalized at the beam isocentre. The dose delivered at the isocentre was equal to 3,7 cGy for a "5 MU" protocol, with a maximum dose of 6 cGy. In the case of the patient considered, the acquisition of 37 MVCBCT corresponded to an additional mean dose to the PTV of 1.2 Gy for a protocol "5MU" with a significant influence on the DVH.

CONCLUSION

In view of this study, it appears that the doses delivered in frequent use of MVCBCT must be taken into account by the radiation oncologist in assessing the therapeutic dose delivered to the target volume and organs at risk.

摘要

目的

研究安装在Oncor Impression直线加速器(西门子)上的兆伏级锥形束计算机断层扫描成像系统(MVCBCT)所输送的剂量。

材料与方法

在治疗计划系统中通过67个光子束(6兆伏)对MVCBCT图像采集进行建模。开展了一项研究以:比较圆柱形模体中心处计算剂量与测量剂量;比较Alderson - Rando模体(骨盆)中计算剂量与测量剂量分布;研究MVCBCT图像采集对接受三维适形放疗(处方剂量74 Gy)的前列腺癌患者重新定位的影响,包括治疗加7次MVCBCT(方案D1 - 3及每周一次)、治疗加37次MVCBCT(治疗的每一天一次)时对剂量体积直方图(DVH)的影响。

结果

圆柱形模体中心处计算剂量与测量剂量之间的差异小于3%。在Rando模体中计算的剂量分布与在射束等中心归一化后的测量剂量之间发现最大偏差为7%。对于“5 MU”方案,等中心处输送的剂量等于3.7 cGy,最大剂量为6 cGy。在所考虑的患者案例中,对于“5MU”方案,采集37次MVCBCT相当于对计划靶体积额外增加平均剂量1.2 Gy,对DVH有显著影响。

结论

鉴于本研究,放射肿瘤学家在评估输送至靶体积和危及器官的治疗剂量时,似乎必须考虑频繁使用MVCBCT时所输送的剂量。

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