Pommier P, Gassa F, Lafay F, Claude L
Service d'oncologie-radiothérapie, centre Léon-Bérard, 69373 Lyon cedex 08, France.
Cancer Radiother. 2009 Sep;13(5):384-90. doi: 10.1016/j.canrad.2009.05.004. Epub 2009 Jul 28.
Image guide radiotherapy with the Cone Beam CT kV (CBCT-kV) developed by Elekta has been implemented at the centre Léon Bérard in November 2006. The treatment procedure is presented and detailed for prostate cancer IGRT and non small cell lung cancer (NSCLC) stereotactic radiotherapy (SRT). CBCT-kV is routinely used for SRT, selected paediatric cancers, all prostate carcinomas, primitive brain tumours and head and neck cancers that do not require nodes irradiation. Thirty-five to 40 patients are treated within a daily 11-hours period. The general procedure for 3D images acquisition and their analysis is described. The CBCT-kV permitted to identify about 10% of prostate cancer patients for whom a positioning with bone-based 2D images only would have led to an unacceptable dose distribution for at least one session. SRT is now used routinely for inoperable NSCLC. The easiness of implementing CBCT-kV imaging and its expected medical benefit should lead to a rapid diffusion of this technology that is also submitted to prospective and multicentric medico-economical evaluations.
由医科达公司研发的带有锥形束CT千伏(CBCT-kV)的图像引导放射治疗于2006年11月在莱昂·贝拉尔中心投入使用。本文介绍并详细阐述了前列腺癌图像引导放射治疗(IGRT)以及非小细胞肺癌(NSCLC)立体定向放射治疗(SRT)的治疗流程。CBCT-kV常规用于SRT、特定的儿科癌症、所有前列腺癌、原发性脑肿瘤以及无需照射淋巴结的头颈癌。每天11小时的时间段内会治疗35至40名患者。描述了三维图像采集及其分析的一般流程。CBCT-kV能够识别出约10%的前列腺癌患者,对于这些患者,如果仅使用基于骨骼的二维图像进行定位,那么至少在一个疗程中会导致不可接受的剂量分布。SRT目前常规用于无法手术的NSCLC。实施CBCT-kV成像的简便性及其预期的医疗效益应会促使该技术迅速推广,该技术也正在接受前瞻性多中心医学经济学评估。