Arapoglou Vassilis, Kondi-Pafiti Agathi, Rizos Demetrios, Kotsis Thomas, Kalkandis Christos, Katsenis Konstantinos
Vascular Surgical Unit, 2nd Surgical Department, Aretaieion Hospital, Medical School, University of Athens, Greece.
Vasc Endovascular Surg. 2009 Oct-Nov;43(5):473-9. doi: 10.1177/1538574409334345. Epub 2009 Jul 29.
Modulating effects of genetic and environmental risk factors on severity of human abdominal aortic aneurysm (AAA) tissue inflammation remain unclear. We investigated the influence of total plasma homocysteine (tHcy) and traditional atherosclerotic risk factors (ARF) on degree of AAA tissue inflammation.
Aneurysm specimens were obtained from 89 male patients aged 52 to 83 years, underwent asymptomatic not ruptured AAA (mean diameter 5.5 cm) open repair and graded for degree of histologic inflammation. Multivariate analysis was used to determine the association of tHcy and ARF, with degree of inflammation.
Current cigarette smoking, odds ratio (OR) 4.4, 95% confidence interval 1.3 to 15.2, P = .01 and no other ARF, neither tHcy levels OR 0.9 (0.9-1.02), P = .2 were associated with high-grade tissue inflammation.
These results provide evidence against a major effect of tHcy levels on AAA tissue inflammation, while current cigarette smoking is a significant modulating factor.
遗传和环境风险因素对人类腹主动脉瘤（AAA）组织炎症严重程度的调节作用尚不清楚。我们研究了血浆总同型半胱氨酸（tHcy）和传统动脉粥样硬化风险因素（ARF）对AAA组织炎症程度的影响。
从89例年龄在52至83岁的男性患者中获取动脉瘤标本，这些患者接受了无症状未破裂AAA（平均直径5.5 cm）开放修复，并对组织学炎症程度进行分级。采用多变量分析确定tHcy和ARF与炎症程度之间的关联。
当前吸烟，比值比（OR）为4.4，95%置信区间为1.3至15.2，P = 0.01，而其他ARF以及tHcy水平（OR为0.9，0.9 - 1.02，P = 0.2）均与高级别组织炎症无关。
这些结果提供了证据，表明tHcy水平对AAA组织炎症无主要影响，而当前吸烟是一个重要的调节因素。
