Takemitsu Tomoko, Ichihara Atsuhiro, Kaneshiro Yuki, Sakoda Mariyo, Kurauchi-Mito Asako, Narita Tatsuya, Kinouchi Kenichiro, Yamashita Norimasa, Itoh Hiroshi
Internal Medicine, Keio University School of Medicine, Tokyo, Japan.
Am J Nephrol. 2009;30(4):361-70. doi: 10.1159/000232199. Epub 2009 Jul 30.
BACKGROUND/AIMS: A significant role of (pro)renin receptor in the pathogenesis of end-organ damage has been suggested only in animal studies. This study was conducted to examine the mRNA expression of (pro)renin receptor in human artery.
In 141 kidney failure patients, the mRNA was harvested from arterial fragments obtained during surgery constructing an arteriovenous access for hemodialysis therapy, and expression levels of (pro)renin receptor and other components of the renin-angiotensin system were determined.
Arterial (pro)renin receptor expression was similar in diabetic and non-diabetic patients, although plasma prorenin levels were significantly higher in the diabetic patients than in the non-diabetic patients. The arterial (pro)renin receptor mRNA levels of the hypertensive patients, who had not been treated with either angiotensin-converting enzyme (ACE) inhibitors or angiotensin II type 1 receptor blockers, were significantly lower than those of the patients who had been treated with either drug. Multiple regression analyses showed a significant association with a large coefficient between the arterial mRNA level of the (pro)renin receptor and the arterial mRNA level of ACE; this significant association disappeared in patients who had been treated with either drug.
(Pro)renin receptor may contribute to the generation of arterial angiotensin II in kidney failure patients.
背景/目的：仅在动物研究中提示了（前体）肾素受体在终末器官损伤发病机制中的重要作用。本研究旨在检测人动脉中（前体）肾素受体的mRNA表达。
在141例肾衰竭患者中，从为血液透析治疗构建动静脉通路手术中获取的动脉片段中提取mRNA，并测定（前体）肾素受体及肾素 - 血管紧张素系统其他成分的表达水平。
糖尿病患者和非糖尿病患者的动脉（前体）肾素受体表达相似，尽管糖尿病患者的血浆前肾素水平显著高于非糖尿病患者。未接受过血管紧张素转换酶（ACE）抑制剂或1型血管紧张素II受体阻滞剂治疗的高血压患者的动脉（前体）肾素受体mRNA水平显著低于接受过其中任何一种药物治疗的患者。多元回归分析显示（前体）肾素受体的动脉mRNA水平与ACE的动脉mRNA水平之间存在显著关联且系数较大；在接受过其中任何一种药物治疗的患者中，这种显著关联消失。
（前体）肾素受体可能在肾衰竭患者动脉血管紧张素II的生成中起作用。
